Summary
Research into how NTS NPY neurons in the brainstem alter NTS circuitry to promote food intake, aiming to understand their role in obesity and develop therapeutic strategies.
How NTS NPY neurons alter NTS circuitry to promote food intake
US · IL
NIH
grant
awarded
#nih-5R01DK138673-02
What they want
The central hypothesis is that NTS NPY neurons release NPY and NE locally to inhibit anorexigenic NTS neurons, with release levels determined by a balance of excitatory vagal drive and GABA inhibition, impacted by fasting and diet. The research will test this hypothesis through three specific aims: 1) Determine the effects of locally released NPY and NE on NTS neuronal function. 2) Elucidate what determines the activity of NTS NPY expressing neurons. 3) Determine whether the activity of NTS NPY neurons and the effects of NPY and NE are altered during a fast and following a high fat high sugar (HFHS) diet.
Deliverables
- Elucidation of the effects of locally released NPY and NE on NTS neuronal function
- Understanding of factors determining the activity of NTS NPY expressing neurons
- Determination of changes in NTS NPY neuron activity and NPY/NE effects during fasting and following a high fat high sugar (HFHS) diet
Risks & flags
- This appears to be a description of an awarded research grant or project, not an open procurement opportunity (RFP, IFB, RFQ).
