Summary
Develop early warning systems for childhood and adult disorders by analyzing dynamic biochemical rhythms in fetal and early postnatal life to predict and prevent disease onset.
Early Warning Systems for Childhood and Adult Disorders
US · IL
NIH
grant
awarded
#nih-5R35ES030435-06
What they want
The project proposes a new paradigm and novel technology to overcome barriers in detecting disorders years before clinical signs appear. It focuses on analyzing highly temporally resolved biochemical rhythms during fetal development and childhood to identify sustained deviations from homeostasis prognostic of later-life disease. This also involves developing a new framework for understanding development as interconnected rhythmic processes embedded within the growth trajectory.
Deliverables
- A novel technology that analyzes dynamic rhythmicity of key biochemical pathways
- A new framework for understanding development as interconnected rhythmic processes
Technical requirements
- Technology must analyze dynamic rhythmicity of key biochemical pathways during fetal development and childhood
- Technology must accurately detect marked and sustained deviations from homeostasis that would be prognostic of later-life disease onset
