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Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PAR-25-323
Response due May 24, 2026 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is offering the Stephen I. Katz Early Stage Investigator (ESI) R01 grant, specifically for basic experimental studies that involve human subjects. This funding opportunity is designed to support early-stage investigators conducting foundational biomedical research with a human experimental component. The grant follows the standard NIH R01 research project grant mechanism. It is posted on Grants.gov under program announcement PAR-25-323.

What they want

This funding opportunity announcement (FOA) supports early stage investigators (ESIs) seeking R01-level research project grant funding for basic experimental studies with humans (BESH). Applicants must be early stage investigators as defined by NIH policy. Research must involve basic experimental studies using human participants, consistent with NIH's definition of clinical trials. Awards are made under the standard R01 grant mechanism administered by NIH.
Technical requirements
  • Research must qualify as Basic Experimental Studies with Humans (BESH) under NIH definition
  • Applicant must hold Early Stage Investigator (ESI) status as defined by NIH
  • Study must involve human participants in a basic research context
  • Application must follow NIH R01 grant application format and requirements

How they evaluate

Submission: Electronic submission via Grants.gov federal grants portal

Eligibility & certifications

NIH Early Stage Investigator (ESI) statusSAM.gov registration (for institutional applicants)Compliance with NIH human subjects research regulations (45 CFR 46)IRB approval for human subjects research

Risks & flags

  • Named grant (Stephen I. Katz) suggests narrowly targeted eligibility criteria — limited to ESIs only, which significantly restricts the applicant pool
  • No dollar value disclosed, making budget planning difficult for applicants
  • BESH classification may impose additional regulatory and reporting burdens that could deter less-experienced applicants

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Stephen I. Katz Early Stage Investigator R…
Due May 24
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