Summary
Clinical resistance to multiple chemically and functionally dissimilar drugs is multifaceted. P-glycoprotein (P-gp, ABCB1) and ABCG2 appear to contribute to this problem due to their broad and overlapping substrate specificities. Both transporters also play an important role in drug-drug interactions as well as in the bioavailability and pharmacokinetics of several drugs. We have designed a coordinated strategy using multidisciplinary approaches in order to understand the molecular basis of the polyspecificity exhibited by P-gp and the mechanism of drug transport. We focused on identifying res
