Summary
This project aims to integrate dynamic MRI and sonomicrometry data from human subjects, phantoms, and cadavers to better understand brain deformation during high-severity impacts and improve TBI injury prediction models.
Biomechanics of the Human Brain During High-Severity Impacts: A Multimodal Approach
US · IL
NIH
grant
open
#nih-1R01NS136056-01A1
What they want
The project addresses fundamental deficiencies in understanding brain deformation during head impact by integrating previously disparate experimental TBI spectrum data. It involves three aims: 1) Optimizing dynamic MRI techniques for increased loading in phantoms and cadavers; 2) Performing multiscale biomechanical characterization of cadaveric specimens using both MRI and sonomicrometry; and 3) Demonstrating the application of combined MRI and sonomicrometry data for improved injury prediction by evaluating publicly available computational models and applying them to sports impact databases.
Deliverables
- Fully characterized phantom data (publicly available)
- Fully characterized cadaveric data (publicly available)
- New tools to predict the response of the living human brain during concussion-level loading
- Improved injury prediction models
Technical requirements
- Dynamic Magnetic Resonance Imaging (MRI)
- Sonomicrometry
- Computational modeling
- Use of phantoms and cadaveric specimens
- Application to sports impact databases
