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Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 Clinical Trial Required)

US National Institutes of Health (NIH) grant open #PAR-25-178
Response due Oct 15, 2027 · 00:00 UTC

Summary

This NIH funding opportunity (PAR-25-178) invites R01 grant applications for pilot hybrid effectiveness-implementation trials focused on mental health interventions. The program seeks to support research that simultaneously tests the effectiveness of mental health interventions and examines their implementation in real-world settings. As a Clinical Trial Required announcement, all applications must include a clinical trial component. The opportunity is posted through Grants.gov and remains open for an extended multi-year period through October 2027.

What they want

Applicants must design and conduct pilot hybrid effectiveness-implementation trials for mental health interventions. The research must integrate both an effectiveness component (testing whether the intervention works) and an implementation component (examining how the intervention can be delivered in real-world settings). A clinical trial is required as part of the study design. Applications must be submitted as R01 research grants through the NIH/HHS funding mechanism.
Technical requirements
  • Clinical trial component is required in all applications
  • Must use R01 grant mechanism
  • Must employ a hybrid effectiveness-implementation trial design
  • Must focus on mental health interventions

How they evaluate

Submission: Grants.gov federal grants portal

Risks & flags

  • Extended open window (nearly 3 years) suggests a broad program announcement rather than a competitive single-award solicitation — multiple awards likely anticipated across rolling submission cycles
  • No dollar figures or award counts disclosed in the synopsis, limiting competitive intelligence

Market context

inferred from NAICS
R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
Pilot Hybrid Effectiveness-Implementation …
Due Oct 15
Onboard ↗