Summary
Research to understand the molecular mechanisms of aging and caloric restriction (CR) in rhesus monkeys, aiming to identify how CR improves healthspan and longevity and to derive translational insights for human aging.
Molecular Networks in Aging and Caloric Restriction in Rhesus Monkeys
US · IL
NIH
grant
awarded
#nih-5R01AG074503-04
What they want
The study aims to determine shared and tissue-specific mechanisms engaged by CR, resolve the life stage-resolved systemic response to CR, and integrate the physiological, systemic, and molecular responses to CR. It involves integrative analysis of high-density molecular profiles within and among tissues from a unique cohort of rhesus monkeys at the Wisconsin National Primate Research Center, linking these data to clinical outcomes, health records, and end-of-life pathology.
Deliverables
- Uncover further regulatory mechanisms engaged during aging and CR at the tissue specific level
- Derive interaction networks within and among tissues to define the molecular details of how CR works
- Relate molecular data to whole animal physiology, health, morbidity, and survival
- Reveal new insights into how aging might be targeted clinically
- Deliver translational insights for human aging
Technical requirements
- Molecular profiling studies
- High-density molecular profiles
- Integrative analysis
