Summary
PROJECT SUMMARY The young brain displays remarkable plasticity. This includes an ability to remodel neuronal synaptic connections to learn new tasks in health, as well as being able to repair connections and restore function after injury. In the adult brain there are active mechanisms in place that maintain neuronal circuit connectivity and synaptic stability, which is necessary for typical brain function, but acts as a barrier to targeted synaptic remodeling in situations where this is beneficial, for example to enhance learning, or to repair neurons after injury. Removal of factors from the
