Summary
This epidemiologic research aims to evaluate the effect of metal co-exposures on cardiometabolic trait trajectories and biological aging during adolescence, leveraging the established Bangladesh Environmental Research in Children's Health (BiRCH) cohort.
What they want
The study will provide insights into early-life health effects of metal exposures, impacts of metal co-exposures, adolescence as a sensitive period for cardiometabolic phenotype programming, and mechanisms by which metal exposures cause cardiometabolic dysfunction. Specific aims include evaluating the association of metal exposures with longitudinal cardiometabolic traits, changes in DNA methylation and DNA methylation age, and changes in leukocyte telomere length during adolescence.
Deliverables
- Insights on early-life health effects of metal exposures
- Insights on impacts of metal co-exposures
- Insights on adolescence as a sensitive period for cardiometabolic phenotype programming
- Insights on mechanisms of action by which metal exposures cause cardiometabolic dysfunction
- Evaluation of association of metal exposures with longitudinal cardiometabolic traits during adolescence
- Evaluation of association of metal exposures with changes in DNA methylation and DNA methylation age during adolescence
- Evaluation of association of metal exposures with changes in leukocyte telomere length during adolescence
- Novel findings for DNA methylation and telomere length as biosensors of metal exposures
