Summary
This research proposal investigates the role of the brain-immune axis and blood-brain barrier impairment in the pathophysiology of neuropsychiatric diseases, focusing on genetic susceptibility through the 22q11.2 deletion syndrome model.
Role of the brain-immune axis in neuropsychiatric disease
US · IL
NIH
grant
open
#nih-5R01MH134797-03
What they want
The study addresses the connectivity of peripheral-neuroinflammation through brain vasculature, its impact on behavior, and their interaction in response to an environmental 'second hit' within the brain-immune axis in the context of genetic susceptibility to neuropsychiatric disease (22qDS). It aims to define links between phenotypes throughout development, determine how the blood-brain barrier (BBB) impacts brain-immune axis responses to environmental 'second hits' and the potential of therapeutic BBB restoration, and identify potential immune therapeutic strategies for brain-immune axis dysfunction to treat behavioral deficits.
Deliverables
- Define the links between different phenotypes throughout development.
- Determine how the BBB impacts brain-immune axis responses to environmental 'second hits' known to trigger symptom onset and the potential of restoring BBB properties therapeutically.
- Identify potential immune therapeutic strategies aiming at brain-immune axis dysfunction to treat behavioral deficits.
