Summary
The uncertain etiology of Alzheimer’s disease poses significant obstacles to the development of both therapeutic and prevention strategies. At the root of this quandary is the fact that familial disease accounts for a very small fraction of cases, with the vast majority remaining genetically sporadic. The most widely known risk factor, the ApoE4 allele of the gene coding for apolipoprotein E, has been identified, but mechanistic ties to disease development are still emerging. Neuroinflammation has long been suspected as a contributing factor, and regular exercise documented as a mitigating fac
