Summary
This project proposes proof-of-concept mechanistic studies to investigate how angiotensin-(1-7) infusion affects cardiovascular and metabolic derangements in obese hypertensive subjects, aiming to identify new therapeutic targets.
Angiotensin-(1-7) and Cardiovascular Derangements in Obesity Hypertension
US · IL
NIH
grant
awarded
#nih-5R01HL170140-02
What they want
The project will conduct mechanistic studies to examine the cardiovascular and metabolic effects of acute intravenous angiotensin-(1-7) infusion in obese hypertensive subjects. Hypotheses to be tested include whether angiotensin-(1-7) can reduce sympathetic activity and blood pressure, improve endothelial function, and increase whole-body insulin sensitivity and insulin-mediated microvascular recruitment. A sub-study will also be performed in pure autonomic failure patients to differentiate direct vascular actions from indirect autonomic mechanisms.
Deliverables
- Results demonstrating the effects of angiotensin-(1-7) on sympathetic activity and blood pressure in obese hypertensive subjects
- Results demonstrating the effects of angiotensin-(1-7) on endothelial function in obese hypertensive subjects
- Results demonstrating the effects of angiotensin-(1-7) on whole-body insulin sensitivity and insulin-mediated microvascular recruitment in obese hypertensive subjects
- Results from sub-study in pure autonomic failure patients clarifying direct versus indirect mechanisms of angiotensin-(1-7) blood pressure and vasodilatory effects
