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Social disconnection and Suicide Risk in Late Life (R21 Clinical Trial Optional)

US National Institutes of Health (NIH) grant open #PAR-25-066
Response due Sep 07, 2026 · 00:00 UTC

Summary

This is a National Institutes of Health (NIH) R21 exploratory/developmental research grant opportunity focused on investigating the relationship between social disconnection and suicide risk in late life (older adults). Clinical trials are optional under this mechanism. The opportunity is posted via Grants.gov under program announcement PAR-25-066 and is administered by the NIH. The grant window spans from November 2024 through September 2026, allowing multiple submission cycles.

What they want

Research grant funding opportunity (PAR-25-066) supporting exploratory and developmental research projects examining social disconnection as a risk factor for suicide in late life (older adult populations). Clinical trial components are optional. Funded under the NIH R21 mechanism, which supports novel, high-impact research that may lack sufficient preliminary data for a standard R01 application.
Technical requirements
  • Research must address social disconnection and suicide risk specifically in late-life/older adult populations
  • Clinical trial component is optional but permitted
  • Must comply with NIH R21 grant mechanism requirements and guidelines
  • Application must be submitted through Grants.gov

How they evaluate

Submission: Grants.gov electronic submission portal

Risks & flags

  • Extremely long open window (nearly 2 years) with no specific submission deadline visible — may have multiple standard NIH receipt dates not disclosed in this synopsis
  • No budget cap or award ceiling stated in the available text; R21 mechanisms typically have implied caps (~$275K direct costs over 2 years) but this is not confirmed here

Market context

inferred from NAICS
R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
Social disconnection and Suicide Risk in L…
Due Sep 07
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