Summary
ABSTRACT Rapid and sensitive point of care tests that can detect all forms of drug resistance are urgently needed to enable appropriate treatment for TB. Molecular drug susceptibility tests (mDSTs) which use nucleic acid amplification techniques to detect mutations associated with resistance to the primary tuberculosis (TB) drugs isoniazid (INH), and rifampin (RIF), and in a few rare cases fluoroquinolones (FQs) have demonstrated the potential of this susceptibility testing approach. However, current mDSTs are unable to detect the large numbers of mutations which encode for resistance to the
