Summary
ALZHEIMER'S DISEASE AND ALZHEIMER'S DISEASE RELATED DEMENTIAS IN PREDIABETES AND TYPE 2 DIABETES: THE DIABETES PREVENTION PROGRAM OUTCOMES STUDY AD/ADRD PROJECT - THIS U19 PROPOSAL FOCUSES ON ONE OF THE MOST IMPORTANT, COMPLEX QUESTIONS IN ALZHEIMER’S DISEASE (AD) AND ALZHEIMER’S DISEASE-RELATED DEMENTIAS (ADRD) RESEARCH: WHAT ARE THE DETERMINANTS AND THE NATURE OF COGNITIVE IMPAIRMENT AMONG PERSONS WITH PRE-DIABETES (PRED) AND TYPE 2 DIABETES (T2D), WHO ARE A HIGH-RISK GROUP FOR COGNITIVE IMPAIRMENT AND REPRESENT A LARGE FRACTION OF THE UNITED STATES (US) POPULATION? DESPITE KNOWLEDGE THAT PERSONS WITH PRED AND T2D ARE A HIGH-RISK GROUP FOR COGNITIVE DECLINE, MILD COGNITIVE IMPAIRMENT (MCI), AND DEMENTIA, THE RISK FACTORS, MECHANISMS, AND NEUROPATHOLOGY OF COGNITIVE IMPAIRMENT IN PERSONS WITH PRED AND T2D REMAIN UNCLEAR. GAPS IN KNOWLEDGE ON COGNITIVE IMPAIRMENT IN PRED AND T2D INCLUDE: (A) THE ROLE OF AD AND/OR NON-AD NEUROPATHOLOGY BEYOND VASCULAR CONTRIBUTIONS TO COGNITIVE IMPAIRME
