Deciphering the role of junctional adhesion molecule-A in neutrophil-driven inflammatory response in Alzheimer disease

Summary

This research project aims to elucidate the critical cellular and molecular events regulating brain endothelial cell-neutrophil interaction in Alzheimer's disease (AD), focusing on the role of junctional adhesion molecule-A (JAM-A) in neutrophil recruitment and inflammatory processes.

What they want

The study will evaluate: a) how a global JAM-A knockout affects vascular and parenchymal neutrophil accumulation and behavioral outcomes in AD; b) the impact of endothelial-associated JAM-A on vascular and parenchymal neutrophil accumulation and behavioral outcomes in AD; c) the cellular and molecular mechanisms underlying the adverse effects of JAM-A in AD; and d) the effects of JAM-A antagonist peptides on AD-induced neutrophil accumulation and behavioral deficits. The research utilizes genetic manipulation of JAM-A and a specifically designed JAM-A antagonist peptide in a mouse AD model.

Deliverables

New information related to the mechanisms of neutrophil accumulation and NETs occurrence relevant to AD and other disease states
Elucidation of novel therapeutic strategies for treatment of AD-associated inflammation