Summary
Summary – Moffitt CSBC Proposal Overview The Moffitt CSBC proposal is focused on the essential and highly dynamical interplay between cancer cell evolution and the constantly changing ecology of the lung microenvironment. Tumors are not simply collections of mutated cells that grow in isolation. Rather, they respond to and modify both the physical microenvironment and a variety of host cells, and these changes in ecology (“∆-Ecology”) are key to understanding tumor progression and the response to therapy – particularly the development of resistance. Central to this proposal is quantifying, un
