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Full-Scale Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 - Clinical Trial Required)

US National Institutes of Health (NIH) grant open #PAR-25-177
Response due Oct 15, 2027 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting R01 grant applications for full-scale hybrid effectiveness-implementation trials focused on mental health interventions. This funding opportunity requires a clinical trial component, meaning applicants must design and conduct research that simultaneously tests the effectiveness of a mental health intervention while also examining implementation strategies. The opportunity is a Program Announcement with Review (PAR), indicating a standing solicitation with multiple receipt dates over a multi-year window running from late 2024 through mid-2027.

What they want

Applicants must design and execute full-scale hybrid effectiveness-implementation trials for mental health interventions. The research must qualify as a clinical trial under NIH definition and must employ a hybrid design that concurrently evaluates: (1) the clinical effectiveness of a mental health intervention on patient outcomes, and (2) implementation strategies for adopting that intervention in real-world settings. Research must adhere to NIH R01 grant mechanism requirements.
Technical requirements
  • Must include a clinical trial component as defined by NIH
  • Must employ a hybrid effectiveness-implementation trial design
  • Must focus on mental health interventions
  • Must comply with NIH R01 grant mechanism requirements

How they evaluate

Submission: Electronic submission via Grants.gov / NIH eRA Commons portal

Eligibility & certifications

SAM registration (Grants.gov submission)NIH eRA Commons registration

Risks & flags

  • Multi-year open window (2024–2027) with rolling receipt dates is standard for NIH PARs — not a red flag in isolation
  • No dollar values stated — award sizes are not disclosed in the synopsis, making budget planning opaque for applicants

Market context

inferred from NAICS
R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
Full-Scale Hybrid Effectiveness-Implementa…
Due Oct 15
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