Summary
Summary Imbalanced levels of neuromodulators and other chemical signals contribute to a host of neurological disorders. Yet, previous studies describing these effects often examine only one molecule at a time, and typically provide a static description of signal levels in the brain or in the cerebrospinal fluid (CSF) that bathes all neurons. In reality, dozens of signals exhibit dynamic changes across states such as quiet waking and social or non-social arousal, which are altered in disease. The tracking and manipulation of patterns of neural activity has been critical to recent neuroscience p