Summary
PROJECT SUMMARY This MIRA/R35 application is designed to replace our NIGMS R01 GM147310-01 and a recent NIGMS R01 application that was scored on first submission but rejected based on not being able to have two simultaneous NIGMS R01s. Following NIGMS advice, I have consolidated these projects into this MIRA application. Our overarching goal is to uncover fundamental cell signaling mechanisms that can be therapeutically targeted in disease. All projects began with PTM discovery approaches and have now grown into multi-pronged efforts that span molecular biology/biochemistry, structural biology
