Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of aging

Summary

This research project aims to deconstruct the interconnectivity and hierarchies among the nine hallmarks of aging by leveraging senolytic CAR T cells to eliminate specific cellular programs like cellular senescence.

What they want

The project involves characterizing the impact of senolytic CAR T cells on antagonistic and integrative hallmarks of aging, developing tissue-specific senolytic CAR T cells to untangle hierarchies across physiological lifespan, and studying the therapeutic potential of modulating these interactions for age-related pathologies. The work builds on preliminary data demonstrating the feasibility and efficacy of senolytic CAR T cells in naturally aged mice, showing significant improvements in healthspan.

Deliverables

Versatile tools to interrogate aging biology
Development of new therapies for a range of age-related pathologies

Technical requirements

Expertise in senescence biology
Expertise in cell engineering technology
Development and application of CAR T cells
Development and application of senolytic CAR T cells