Summary
This project aims to understand the cellular and circuit bases by which parafacial zone (PZ) neurons in the brainstem promote sleep, specifically slow-wave sleep (SWS), to inform the development of new sleep aids.
Brainstem circuitry for sleep-wake control
US · IL
NIH
grant
awarded
#nih-5R01NS119597-05
What they want
The project will investigate the cellular and synaptic circuit basis by which PZ neurons control sleep, testing the central hypothesis that a sub-population of PZ GABAergic neurons is both sufficient and necessary for the generation of SWS and cortical slow-wave activity (SWA). Specific aims include uncovering a sleep-promoting PZ GABAergic sub-population and elucidating the neuronal circuits by which these neurons directly influence cortical activity.
Technical requirements
- Genetically-driven lesions
- Chemogenetic activation/inhibition
- Optogenetic activation/inhibition
- Fiber photometry
- Neuronal tracing
- In vitro electrophysiology
- In vivo Ca2+ imaging
- Thalamic lesioned mice
Market context
inferred from NAICSR&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
- US market size
- $95B
- Typical award
- $100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
