Summary
This project aims to investigate the fundamental mechanisms mediating sex-based differences in cardiovascular lesion development in Kawasaki Disease (KD) vasculitis, specifically focusing on IL-1β-mediated immune-stromal cell interactions.
Role of Sex in Immune Stromal cell Interactions driving cardiovascular lesions in Kawasaki Disease vasculitis
US · IL
National Institutes of Health
grant
awarded
#nih-5R01HL170580-02
What they want
The research will test the hypothesis that differences in IL-1β-mediated immune-stromal cell interactions drive sex disparity in KD. This involves two aims: 1) establishing the contribution of monocytes, macrophages, and neutrophils to disease pathogenesis in male and female mice during LCWE-induced KD vasculitis, and 2) establishing the contribution of sex differences in vascular smooth muscle cell function to sexual dimorphism in LCWE-induced vasculitis. The ultimate goal is to identify novel therapeutic approaches for KD.
