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Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)

US · US National Institutes of Health – National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant open #PAR-25-068
Response due Nov 16, 2027 · 00:00 UTC

Summary

This NIH funding opportunity (PAR-25-068) invites R21 pilot study applications exploring biological, behavioral, and social mechanisms that contribute to HIV pathogenesis, specifically within the scientific mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Clinical trials are explicitly excluded. The R21 mechanism is designed to support exploratory and developmental research projects. The opportunity is open from January 2025 through November 2027, indicating a multi-cycle, standing announcement.

What they want

Applicants must propose pilot/exploratory studies investigating the biological, behavioral, and/or social mechanisms by which HIV contributes to pathogenesis in disease areas within the NIDDK mission (e.g., diabetes, digestive diseases, kidney diseases, obesity, hematology). Clinical trials are not allowed under this announcement. The R21 grant mechanism supports early-stage, hypothesis-generating research with a two-year project period and defined budget limits typical of R21 awards.
Deliverables
  • Pilot/exploratory research findings on HIV pathogenesis mechanisms
  • Progress reports per NIH reporting requirements
  • Final research report and data sharing per NIH policy
Technical requirements
  • Research must fall within the NIDDK scientific mission (diabetes, digestive diseases, kidney diseases, obesity, hematology, etc.)
  • Clinical trials are not allowed
  • R21 exploratory/developmental research mechanism applies
  • Pilot/feasibility study design required

How they evaluate

  • Scientific and technical merit (peer review by NIH study section)
  • Significance and innovation
  • Approach and feasibility
  • Investigator qualifications
  • Environment and institutional support
Submission: Electronic submission via Grants.gov and NIH ASSIST/eRA Commons portal

Eligibility & certifications

SAM.gov registration (for institutional applicants)Compliance with NIH human subjects and data sharing policiesInstitutional assurances (IRB, animal welfare as applicable)

Risks & flags

  • Standing multi-year announcement (Jan 2025 – Nov 2027) suggests multiple submission cycles, which is normal for NIH PARs but warrants tracking of specific due dates not listed in this synopsis
  • No explicit budget cap stated in the synopsis — applicants should consult full FOA for R21 direct cost limits (typically $275,000 over 2 years)
  • Restriction to NIDDK mission areas narrows eligible research scope significantly and may favor applicants with established NIDDK relationships

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Pilot Studies of Biological, Behavioral an…
Due Nov 16
Onboard ↗