Summary
This research project aims to investigate the inhibitory mechanisms of galectin-3 on corneal nerve regeneration to develop novel therapeutic strategies for corneal diseases such as neurotrophic keratopathy and dry eye.
Galectin-3 and corneal nerve regeneration
US
NIH
grant
open
#nih-5R01EY035702-03
What they want
The project will examine the role of galectin-3 in modulating neurotrophic signaling, determine its impact on neural mechanisms underlying corneal disease, and investigate whether therapeutic inhibition of galectin-3 improves corneal nerve regeneration and sensation.
Deliverables
- Reveal a novel mechanism by which galectin-3 regulates neurotrophic signaling in corneal nerves
- Advance the field of corneal nerve regeneration by targeting pathological actions of galectin-3
- Lead to the development of novel therapies to promote functional innervation
