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Dynamics of hematopoietic differentiation

US National Cancer Institute grant open #nih-1ZIABC011781-09

Summary

We finalized a manuscript detailing our most recent experimental results and modeling effort. This paper was submitted to biorxiv and is being adjusted to address reviewers' comments. Homeostatic hematopoiesis is a dynamical process, characterized by large variations of cell frequencies, cell proliferation rates and extensive correlations/anti-correlations within the myeloid lineage or the lymphoid lineage, and between lineages. All cell types exhibit rare but synchronized bursts of proliferation in the bone marrow, blood and spleen. We show that this abnormal cell accumulation drives the chao

Dynamics of hematopoietic differentiation
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