Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition

The study will investigate the hypothesis that lower anandamide (AEA) concentrations during the menopause transition are linked to decreased estradiol concentrations and increased trauma-related hyperarousal (TRH). It will utilize a combination of psychological assessments, fear conditioning paradigms, and biological measures to provide a comprehensive understanding of the mechanisms driving TRH exacerbation during perimenopause. The findings are intended to inform the development of targeted interventions for trauma-exposed women during this critical period of vulnerability.