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INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)

US · US National Institutes of Health (NIH) grant open #RFA-OD-27-003
Response due Jun 15, 2028 · 00:00 UTC

Summary

The NIH INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project is soliciting Exploratory/Developmental Research Awards (R21 mechanism) focused on Down syndrome research. Clinical trials are explicitly excluded from this funding opportunity. The award is intended to support early-stage, innovative research that advances understanding of Down syndrome and co-occurring conditions. This is a federal grant opportunity administered through Grants.gov under the National Institutes of Health.

What they want

Applicants are invited to submit R21 Exploratory/Developmental Research grant applications under the NIH INCLUDE Project to investigate Down syndrome. Clinical trials are not allowed under this funding opportunity announcement (FOA RFA-OD-27-003). Research is expected to be exploratory or developmental in nature, consistent with the R21 activity code, which supports novel scientific ideas or new model systems, tools, or technologies with the potential to significantly advance biomedical research relevant to Down syndrome and co-occurring conditions across the lifespan.
Technical requirements
  • Clinical trials are not allowed under this funding opportunity
  • R21 Exploratory/Developmental Research activity code mechanism applies
  • Research must focus on Down syndrome and/or co-occurring conditions across the lifespan

How they evaluate

  • Scientific and technical merit as assessed by NIH peer review (study section)
  • Innovation and exploratory/developmental nature of proposed research
  • Relevance to the INCLUDE Project mission and Down syndrome research priorities
Submission: Electronic submission via Grants.gov federal grants portal

Risks & flags

  • No dollar value or award ceiling disclosed in the synopsis
  • Multi-year open window (May 2026 – June 2028) suggests rolling submission cycles — specific due dates per cycle not provided in this record
  • Only a synopsis docType is posted; full FOA details not included in the provided text

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

INCLUDE Project: Exploratory/Developmental…
Due Jun 15
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