Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R01 Clinical Trial Optional)

US National Institutes of Health (NIH) grant open #PAR-25-065

Response due Sep 07, 2026 · 00:00 UTC

Summary

This NIH funding opportunity (PAR-25-065) solicits R01 research grant applications focused on novel mechanism research into neuropsychiatric symptoms (NPS) associated with Alzheimer's dementia. The program is open to both clinical trial and non-clinical trial research designs. It is administered by the National Institutes of Health under the Department of Health and Human Services. The opportunity opened in November 2024 and accepts applications through September 2026.

What they want

Technical requirements

Research must address novel mechanisms underlying neuropsychiatric symptoms in Alzheimer's dementia
Clinical trial component is optional — both clinical trial and non-clinical trial designs are eligible
Must conform to NIH R01 grant application requirements

How they evaluate

Submission: Grants.gov federal grants portal submission (electronic)

Risks & flags

Extremely long open window (nearly 2 years) with rolling submissions typical of NIH program announcements — not a competitive RFP; award selection is peer-review driven and may favor established research institutions with prior NPS/Alzheimer's publication records

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541711

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Novel Mechanism Research on Neuropsychiatr…

Due Sep 07

Onboard ↗