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Investigator Initiated Innovation in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)

US · MD · Bethesda National Institutes of Health (NIH) grant open #PAR-25-229
Response due Sep 07, 2027 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting investigator-initiated R21 exploratory/developmental research grant applications focused on innovation in computational genomics and data science. Clinical trials are explicitly not allowed under this funding opportunity. The R21 mechanism supports early-stage, high-risk/high-reward research projects in computational and data science approaches applied to genomics. This is a standing program announcement open from November 2024 through September 2027, inviting submissions on a rolling basis.

What they want

Applicants must propose investigator-initiated, innovative research projects in the domains of computational genomics and data science. Research must be exploratory or developmental in nature (consistent with the NIH R21 mechanism). Clinical trials are explicitly excluded. Projects should advance novel computational methods, algorithms, tools, or data science approaches relevant to genomics. Submissions are accepted on a rolling basis within the open period of the announcement (PAR-25-229).
Technical requirements
  • Research must be investigator-initiated
  • Clinical trials are not allowed
  • Must align with R21 exploratory/developmental research mechanism
  • Focus on computational genomics and/or data science innovation

How they evaluate

Submission: Electronic submission via Grants.gov (federal grants portal), consistent with standard NIH R21 application requirements

Risks & flags

  • No dollar value or budget cap disclosed in the available text — award size is unclear
  • Rolling deadline spanning nearly 3 years may obscure true priority review cycles

Market context

inferred from NAICS
R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
Investigator Initiated Innovation in Compu…
Due Sep 07
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