Keeping fat out of muscle - Role of Branched Amino AcidsAmino Acids in Insulin Resistance

Summary

This research supplement investigates the molecular signaling pathways by which branched-chain amino acid (BCAA) catabolism promotes vascular smooth muscle cell relaxation and glucose disposal, specifically focusing on the role of histone acetylation.

What they want

The project aims to test the hypothesis that BCAA catabolism promotes transcription of genes that enhance VSMC relaxation via histone acetylation (Aim 1) and to assess whether histone acetylation drives VSMC relaxation and improves glucose disposal using in vivo histone acetyltransferase and deacetylase inhibitors (Aim 2). The research seeks to identify new epigenetic targets for enhancing vascular function and insulin sensitivity, potentially leading to novel therapies for Type 2 Diabetes Mellitus and cardiovascular disease. Additionally, it provides crucial training for a physician-scientist candidate in translational diabetes research.

Deliverables

Research findings on molecular signaling pathways linking BCAA metabolism to vasodilation and insulin sensitivity
Identification of new epigenetic targets for enhancing vascular function and insulin sensitivity
Training for a physician-scientist candidate in translational diabetes research

Key personnel

physician-scientist candidate