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EPSCoR Research Infrastructure Improvement Program: EPSCoR Collaborations for Optimizing Research Ecosystems

US U › S › National Science Foundation (NSF) grant open #25-523
Response due Jul 21, 2026 · 00:00 UTC

Summary

The U.S. National Science Foundation (NSF) is soliciting applications under the EPSCoR Research Infrastructure Improvement (RII) Program, specifically the "Collaborations for Optimizing Research Ecosystems" (CORE) track. This program is designed to strengthen research infrastructure and capacity in EPSCoR-eligible jurisdictions (states and territories that historically receive a smaller share of federal R&D funding). The solicitation aims to foster collaborative efforts that optimize research ecosystems, likely through partnerships among academic institutions, industry, and government entities. The opportunity has a notably long open window, running from December 2024 through July 2026.

What they want

Technical requirements
  • Applicant must be located in or affiliated with an EPSCoR-eligible jurisdiction
  • Proposed work must align with research infrastructure improvement and ecosystem optimization goals
  • Must comply with NSF grant application requirements and Grants.gov submission standards

How they evaluate

Submission: Grants.gov federal grants portal

Risks & flags

  • Extremely long response window (~19 months) may indicate a rolling or phased solicitation rather than a standard competitive RFP — applicants should verify specific deadline tracks within the solicitation.
  • Minimal descriptive detail provided in the synopsis; full program solicitation (NSF 25-523) should be reviewed for complete requirements, eligibility restrictions, and funding caps.
  • EPSCoR eligibility is jurisdictionally restricted — only applicants from qualifying EPSCoR states/territories may apply, which inherently narrows the competitive pool.

Market context

inferred from NAICS
R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
EPSCoR Research Infrastructure Improvement…
Due Jul 21
Onboard