Identifying ancestry-specific and distal components of disease-associated gene regulation and cellular function

Summary

This project aims to develop new algorithms to robustly map disease-associated genetic variants to disease-critical genes and infer their cell-type-specific regulatory behavior, particularly focusing on understudied non-European populations.

What they want

The project will develop new algorithms to robustly map disease-associated variants to disease-critical genes and infer their cell-type-specific regulatory behavior. This involves three main aims: 1) developing a novel gene-disease mapping technique for understudied non-European populations to discover new disease-critical genes; 2) developing a high-dimensional feature selection technique to detect distal effects on gene expression, linking distal regulatory variants to target genes; and 3) linking variants to genes in cell-type-specific contexts using mixed models for heritability estimation by analyzing rare cell types from single cell RNA-sequencing.

Deliverables

New algorithms for robustly mapping disease-associated variants to disease-critical genes
Algorithms to infer cell-type-specific regulatory behavior
A novel gene-disease mapping technique for understudied populations
A high-dimensional feature selection technique to detect distal effects on gene expression
Methods to link variants to genes in cell-type-specific contexts using mixed models for heritability estimation

Technical requirements

Genome-wide association studies (GWAS) analysis
Expression quantitative trait loci (eQTL) studies
Development of new algorithms
High-dimensional feature selection techniques
Single cell RNA-sequencing analysis
Mixed models for heritability estimation
Gene expression prediction models

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541714

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.