PHYSICAL REHABILITATION FOR OLDER PATIENTS WITH ACUTE HFPEF-THE REHAB-HFPEF TRIAL - ACUTE DECOMPENSATED HEART FAILURE (ADHF) IS THE LEADING CAUSE OF HOSPITALIZATION IN OLDER PERSONS, AND IS ASSOCIATED WITH MARKED PHYSICAL DISABILITY, POOR HEALTH-RELATED QUALITY OF LIFE (HRQOL), FREQUENT REHOSPITALIZATIONS, LOSS OF INDEPENDENCE, HIGH MORTALITY, AND ENORMOUS HEALTH CARE COSTS. HOWEVER, MOST OF THE TRIALS TESTING A WIDE RANGE OF MEDICATIONS AND STRATEGIES IN ADHF HAVE BEEN NEUTRAL. IN OUR RECENTLY COMPLETED NIA-FUNDED PHASE 2 TRIAL (REHAB-HF), AN INNOVATIVE, EARLY, TRANSITIONAL, TAILORED, AND PROGRESSIVE MULTI-DOMAIN PHYSICAL REHABILITATION INTERVENTION PRODUCED A LARGE IMPROVEMENT IN THE PRIMARY OUTCOME OF SHORT PHYSICAL PERFORMANCE BATTERY (+1.5 POINTS) IN OLDER PATIENTS WITH ADHF. AT BASELINE, THE PARTICIPANTS (53%) WITH HF WITH PRESERVED EJECTION FRACTION (HFPEF), HAD SIGNIFICANTLY WORSE IMPAIRMENTS IN PHYSICAL FUNCTION, FRAILTY, HRQOL, AND DEPRESSION THAN THOSE WITH HF WITH REDUCED E

Summary

PHYSICAL REHABILITATION FOR OLDER PATIENTS WITH ACUTE HFPEF-THE REHAB-HFPEF TRIAL - ACUTE DECOMPENSATED HEART FAILURE (ADHF) IS THE LEADING CAUSE OF HOSPITALIZATION IN OLDER PERSONS, AND IS ASSOCIATED WITH MARKED PHYSICAL DISABILITY, POOR HEALTH-RELATED QUALITY OF LIFE (HRQOL), FREQUENT REHOSPITALIZATIONS, LOSS OF INDEPENDENCE, HIGH MORTALITY, AND ENORMOUS HEALTH CARE COSTS. HOWEVER, MOST OF THE TRIALS TESTING A WIDE RANGE OF MEDICATIONS AND STRATEGIES IN ADHF HAVE BEEN NEUTRAL. IN OUR RECENTLY COMPLETED NIA-FUNDED PHASE 2 TRIAL (REHAB-HF), AN INNOVATIVE, EARLY, TRANSITIONAL, TAILORED, AND PROGRESSIVE MULTI-DOMAIN PHYSICAL REHABILITATION INTERVENTION PRODUCED A LARGE IMPROVEMENT IN THE PRIMARY OUTCOME OF SHORT PHYSICAL PERFORMANCE BATTERY (+1.5 POINTS) IN OLDER PATIENTS WITH ADHF. AT BASELINE, THE PARTICIPANTS (53%) WITH HF WITH PRESERVED EJECTION FRACTION (HFPEF), HAD SIGNIFICANTLY WORSE IMPAIRMENTS IN PHYSICAL FUNCTION, FRAILTY, HRQOL, AND DEPRESSION THAN THOSE WITH HF WITH REDUCED E