Summary
Investigating the contribution of a novel monocyte transcriptional state to sepsis immunopathogenesis and patient heterogeneity using single-cell RNA sequencing and functional immunological assays.
Investigating the contribution of a novel monocyte transcriptional state to sepsis immunopathogenesis and patient heterogeneity
US · IL
NIH
grant
awarded
#nih-1K08AI185298-01A1
What they want
This project will apply single-cell RNA sequencing (scRNA-seq) and functional immunological assays to investigate the immunomodulatory role of monocyte substate 1 (MS1) and its contribution to patient heterogeneity in sepsis. The findings are expected to advance understanding of sepsis immunopathogenesis, resolve phenotypic heterogeneity, and guide development of subtype-specific treatment strategies. The project includes a five-year career development plan for the candidate, focusing on transcriptomic, computational, and functional analysis of host immune responses to infection, with didactic and hands-on training in computational genomics and systems immunology.
Technical requirements
- Single-cell RNA sequencing (scRNA-seq)
- Functional immunological assays
- Transcriptomic analysis
- Computational analysis
- Functional analysis of host immune responses
Key personnel
- Instructor in Medicine at Harvard Medical School / Assistant in Medicine in the Division of Infectious Diseases at Massachusetts General Hospital (candidate)
- Dr. Nir Hacohen (co-mentor)
- Dr. Roby Bhattacharyya (co-mentor)
- Committee of established scientists (career advisement)
Risks & flags
- Specific individual named as recipient/researcher
