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NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required)

US · MD National Institutes of Health (NIH) grant open #PAR-25-049
Response due Jul 09, 2026 · 00:00 UTC

Summary

This is a National Institutes of Health (NIH) funding opportunity announcement (FOA) for neurologic clinical trials under the SIREN (Strategies to Innovate EmeRgENcy Care Clinical Trials Network) program. The opportunity uses a UG3/UH3 phased award mechanism, where UG3 represents a milestone-driven planning phase and UH3 represents the subsequent implementation/trial phase. A clinical trial is explicitly required. The FOA is open for submissions from November 2024 through July 2026, indicating a multi-cycle announcement.

What they want

Applicants must propose and conduct neurologic clinical trials under the NIH SIREN network framework. The award mechanism is a two-phase cooperative agreement: UG3 (planning/milestone phase) transitioning to UH3 (trial implementation phase). A clinical trial is a mandatory component of the proposed research. The solicitation is administered by the National Institutes of Health (agency code HHS-NIH11).
Technical requirements
  • Clinical trial is required — proposals without a clinical trial component will not be accepted
  • Two-phase award mechanism: UG3 (planning with milestones) transitioning to UH3 (implementation)
  • Must align with NIH SIREN (Strategies to Innovate EmeRgENcy Care Clinical Trials Network) framework
  • Neurologic focus area required

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Risks & flags

  • Very long open window (Nov 2024 – Jul 2026) may indicate multiple due dates not captured in this synopsis — actual submission deadlines likely differ from the close date
  • Minimal detail provided in the synopsis; full Program Announcement (PAR-25-049) must be reviewed for complete requirements, budget caps, and eligibility
  • SIREN network participation may implicitly favor institutions already embedded in the SIREN infrastructure, limiting competitive access for new entrants

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

NIH SIREN Neurologic Clinical Trials (UG3/…
Due Jul 09
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