Summary
The ileal apical sodium-dependent bile acid transporter (ASBT) is crucial for the enterohepatic circulation of bile acids and plays a key role in maintaining bile acid, lipid, and cholesterol balance. Emerging evidence suggests that ASBT is an attractive therapeutic approach to restore metabolic functions and lower plasma cholesterol. This is particularly important in light of recent findings indicating the need to lower cholesterol to very low levels in individuals with high risk for developing cardiovascular diseases (CVDs) such as the veterans. Achieving such stringent target remains challe
