Summary
PROJECT SUMMARY Abuse of psychostimulants represents a major public health problem in the United States. Continued misuse of stimulants escalates in vulnerable individuals to a substance use disorder (SUD). SUDs are debilitating conditions evidenced by sustained, clinically significant health consequences and there is a critical unmet need to discover therapeutic strategies to normalize mechanistic drivers of cocaine use disorder (CUD) and treat CUD effectively. Using an informatics approach comparing RNA expression in human brain subregions versus other tissues, we identified GPR52, a novel o
