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Continuation or Revision of NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UH3 Clinical Trial Required)

US National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), HHS grant open #PAR-25-062
Response due Jan 06, 2028 · 00:00 UTC

Summary

This is a federal grant opportunity from the National Institute of Dental and Craniofacial Research (NIDCR) under NIH, soliciting applications for the continuation or revision of a Clinical Trial Planning and Implementation Cooperative Agreement under the UH3 activity code. The opportunity requires a clinical trial component and is structured as a cooperative agreement, meaning NIH staff will have substantial programmatic involvement. It is posted as a Program Announcement with Review (PAR), indicating a standing opportunity open over a multi-year window through January 2028.

What they want

Applicants must propose the continuation or revision of an NIDCR-funded clinical trial planning and implementation project under the UH3 cooperative agreement mechanism. A clinical trial is required. NIH/NIDCR will maintain substantial programmatic involvement in the conduct of the award. The UH3 phase typically represents the implementation phase following a UH2 planning phase. Applicants are expected to advance an already-planned clinical trial into or through full implementation.
Technical requirements
  • Clinical trial required (UH3 activity code)
  • Must represent a continuation or revision of an existing NIDCR UH2/UH3 cooperative agreement
  • Substantial NIH programmatic involvement as a cooperative agreement

How they evaluate

Submission: Grants.gov electronic submission portal (grants.gov)

Risks & flags

  • Opportunity appears restricted to existing NIDCR UH2/UH3 awardees (continuation/revision only), limiting competition to incumbents
  • PAR mechanism with very long open window (2024–2028) may favor established research teams with prior NIDCR relationships

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Continuation or Revision of NIDCR Clinical…
Due Jan 06
Onboard ↗