Summary
Develop absolute 3D whole-brain thermography using novel multinuclear MRI to detect and characterize ischemic cerebral hyperthermia in stroke patients.
Absolute Brain Thermography using Multinuclear MRI
US · IL
NIH RePORTER
grant
awarded
#nih-5R01EB034820-03
What they want
The project aims to overcome fundamental limitations of current MR thermometry (MRT) using proton resonance frequency (PRF) chemical shift, such as environmental alterations, magnetic field fluctuations, and low temperature sensitivity. It proposes to use novel multinuclear thermometry developed by the investigators, which shows heightened immunity to B0 drift, susceptibility, pH, and higher signal-to-noise ratio, to achieve unprecedented accuracy in absolute 3D whole-brain thermometry.
Deliverables
- absolute 3D whole-brain thermometry for detection and characterization of ischemic cerebral hyperthermia
Technical requirements
- Multinuclear MRI
- MR thermometry (MRT) using proton resonance frequency (PRF) chemical shift with 1H-MR spectroscopy (MRS)
- Novel multinuclear thermometry with heightened immunity to B0 drift, susceptibility, and pH, and higher SNR per-unit time
