Sex Dimorphism in Age-Related Knee Osteoarthritis

Summary

This research project proposes to investigate the sex- and age-dependent mechanisms by which changes in the chondrocyte microenvironment, specifically soluble factors and extracellular matrix stiffening, drive knee osteoarthritis (KOA) pathogenesis.

What they want

The project will mechanistically interrogate the direct role of soluble microenvironmental factors (Aim 1) and the contribution of extracellular matrix (ECM) biophysical properties (Aim 2) on the loss of cartilage integrity with aging and according to sex. This will be achieved using an in vitro and in vivo biofluid exchange model, an advanced network medicine approach integrated with machine learning algorithms, and a physiologically relevant model of female aging involving chemically-induced menopause in middle-aged mice.

Deliverables

Mechanistic insights into how sex impacts cartilage physiology over time
Aid in the development of effective interventions that consider sex-specific variables for the aging population

Technical requirements

In vitro and in vivo biofluid exchange model
Advanced network medicine approach integrated with machine learning algorithms
Physiologically relevant model of female aging by which menopause is chemically-induced in middle-aged mice

Key personnel

Stem cell biologist (PI)
Computational biologist (co-PI)
Bioengineer (co-I)