Summary
PROJECT SUMMARY: The synthesis of biologically active molecules through selective C–C bond-forming reactions is central to the discovery of new therapeutics. Though forging C–C bonds is often more challenging at C(sp3)-centers than C(sp2)-centers, especially when new stereocenters emerge, clinical success is correlated with sp3-richness. Consequently, developing new methods to rapidly generate complex, sp3-rich compounds from simple starting materials presents an opportunity for synthetic innovation to accelerate the discovery of new medicines. Nature constructs bioactive molecules using enzym
