Summary
Project Summary The goal of this research program is to elucidate the proteins and mechanisms that regulate transcription within the context of chromatin, a process critical to every eukaryotic cell. Nucleosomes pose barriers to RNA polymerase II (Pol II) that must be overcome for accurate and efficient gene expression, and whose properties and interactions are modulated by post-translational modification. During transcription elongation, a conserved set of factors assembles with Pol II and facilitates its transit by altering the stability, positioning, and post- translational modification sta
