Summary
Pre-clinical studies using a modified in vivo mouse model to assess therapies for Myelodysplastic Syndrome (MDS), including FDA-approved and novel DNA methyltransferase inhibitors and other agents.
Pre-clinical Studies of Therapy for Myelodysplastic Syndrome
US · IL
NIH
grant
open
#nih-1ZIABC010983-18
What they want
The project involves developing and refining a chimeric mouse model of MDS without ionizing radiation, using it to test the efficacy of various compounds (DNMTi, CXCR1/2 inhibitors, kinase inhibitors, HDAC inhibitors, apoptosis inhibitors, and angiogenesis inhibitors), and studying mechanisms of drug toxicity. It also includes collaborations with other academic institutions and industry partners, and publishing research findings.
