Summary
ADULT CHANGES IN THOUGHT (ACT) RESEARCH PROGRAM - THE ADULT CHANGES IN THOUGHT (ACT) U19 PROGRAM WILL EXPAND, MODERNIZE, AND IMPROVE ACT'S PROSPECTIVE COHORT STUDY TO ACHIEVE ADVANCES IN SCIENTIFIC UNDERSTANDING OF OLDER ADULTS IN GENERAL AND DEMENTIA AND ALZHEIMER'S DISEASE IN PARTICULAR. ACT IS SET IN A HEALTHCARE DELIVERY SYSTEM. THE STUDY TEAM IDENTIFIES INCIDENT CASES OF DEMENTIA AND ALZHEIMER'S DISEASE AND FOLLOWS CONSENTING PARTICIPANTS TO AUTOPSY. THE PROGRAM WILL TRANSFORM THE CURRENT ACT U01 TO A U19, WHICH ENVISIONS COMPLEX MULTI-COMPONENT PROGRAMS THAT WILL HAVE A POWERFUL INFLUENCE ON THE FIELD. THE PROGRAM'S OVERARCHING GOAL IS TO IDENTIFY RISK FACTORS ACROSS THE LIFE COURSE THAT PROVIDE POTENTIAL INTERVENTION TARGETS FOR PRESERVING COGNITION AND PREVENTING ALZHEIMER'S DISEASE AND RELATED DEMENTIAS (ADRD). THE OVERALL SPECIFIC AIMS ARE: AIM 1. EXPAND ACT COHORT ENROLLMENT AND MODERNIZE AND IMPROVE FOLLOW-UP WITH EMPHASIS ON INCREASING RACIAL/ETHNIC DIVERSITY AND DEEP PHEN
