Summary
A prospective cohort study will investigate the association between cannabis use trajectories and cardiovascular health outcomes, including risk status and underlying mechanisms, in adult patients with early-stage high blood pressure in Michigan.
What they want
Recruit a prospective cohort of adult patients with early-stage high blood pressure from primary care clinics in Michigan. Collect data through detailed questionnaires, physical exams, and biospecimen collections over a 30-month study period. Characterize cannabis use trajectories, estimate their association with cardiovascular risk status, and estimate their association with underlying mechanisms of cardiovascular disease (systemic inflammation, platelet aggregation, arterial vasospasm). The study will account for cannabis potency and route of administration, adapting a mobile pharmacology laboratory approach to assess the potency of cannabis products available to patients in Michigan.
Deliverables
- Characterization of cannabis use trajectories among patients with high blood pressure
- Estimates of the association between cannabis use trajectories and cardiovascular risk status
- Estimates of the association between cannabis use trajectories and underlying mechanisms of cardiovascular disease (systemic inflammation, platelet aggregation, arterial vasospasm)
- Information to inform cannabis policies, medical cannabis recommendations, and public health harm reduction strategies
Technical requirements
- Prospective cohort study design
- Detailed questionnaires for data collection
- Physical exams for data collection
- Biospecimen collections for data collection
- Mobile pharmacology laboratory approach for cannabis potency assessment
