Channelopathies of Inflammation

Summary

Research into the molecular mechanisms by which IL-6 signaling contributes to ventricular tachyarrhythmias (VT) in obesity, and to evaluate the anti-arrhythmic potential of IL-6 signaling inhibition.

What they want

The project aims to elucidate the molecular mechanism(s) by which IL-6 signaling triggers dramatic and arrhythmogenic electrical changes in vitro and to determine in vivo anti-IL-6 signaling anti-arrhythmic efficacy using a guinea pig high-fat diet-induced inflammation model. This involves two specific aims: 1) determining the anti-arrhythmic effects of IL-6 signaling inhibition, and 2) identifying the mechanism(s) of arrhythmogenesis by over-stimulation of IL-6 trans-signaling. The research will utilize Langendorff perfused guinea pig hearts, telemetered guinea pigs, guinea pig and human epicardial adipose-tissue derived secretome, and guinea pig ventricular myocytes.

Deliverables

Scientific justification for the continued development and future clinical trials of anti-cytokine drugs for ventricular tachyarrhythmias

Technical requirements

Langendorff perfused guinea pig hearts
Telemetered guinea pigs
Guinea pig and obese/heart failure human epicardial adipose-tissue derived secretome
Guinea pig ventricular myocytes
Hyper-IL-6 methodologies
Olamkicept methodologies and assays

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541714

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.