Summary
This project proposes to test three novel tools for measuring the community burden and impact of typhoid conjugate vaccines in low- and middle-income countries, leveraging an ongoing vaccine trial in Vellore, India.
Novel tools for measuring typhoid vaccine impact
US · IL
NIH RePORTER
grant
open
#nih-5R01AI181283-02
What they want
The project will leverage a large, cluster-randomized trial of a typhoid conjugate vaccine in Vellore, India, to rigorously test three emerging tools for measuring community burden of typhoid: 1) seroepidemiological models using S. Typhi antigen seroresponses; 2) detection of S. Typhi-specific bacteriophages in wastewater using low-cost assays; and 3) phylodynamic methods to track transmission intensity. The goal is to provide scalable public health tools for typhoid surveillance in resource-constrained settings to inform vaccine introductions and monitor their impact.
Deliverables
- Rigorous testing of seroepidemiological models for typhoid surveillance
- Rigorous testing of S. Typhi-specific bacteriophage detection in wastewater
- Rigorous testing of phylodynamic methods for tracking typhoid transmission intensity
- Public health tools for scalable typhoid surveillance in resource-constrained settings
Technical requirements
- Seroepidemiological models utilizing recently characterized seroresponses to S. Typhi antigens
- Detection of S. Typhi-specific bacteriophages in wastewater using low-cost assays
- Phylodynamic methods that track measures of transmission intensity
