Summary
Research on chemically modified Peptide Nucleic Acids (PNAs), specifically "thyclotides," for detecting nucleic acid sequences related to diseases and pathogens, and for developing small molecule enzyme inhibitors and medical diagnostics.
Chemically Modified Peptide Nucleic Acids
US · IL
NIH
grant
open
#nih-1ZIADK031143-21
What they want
The research involves synthesizing non-natural PNAs (thyclotides) designed to bind specific DNA or RNA sequences. This includes refining novel detection assays for disease-associated RNA, exploring small molecule enzyme inhibitors, integrating molecules into medical diagnostics platforms, and expanding thyclotide technology for enhanced cellular uptake of cargo molecules.
Deliverables
- Published manuscripts on thyclotides
- Refined novel detection assay using thyclotide molecules to detect RNA associated with diseases
- Extended study exploring the potential development of small molecule enzyme inhibitors
- Integration of molecules into technological platforms for medical diagnostics
Technical requirements
- Synthesis of non-natural molecules (PNAs)
- Design molecules to bind to specific DNA or RNA sequences
- Development and application of thyclotides
- Development of novel detection assays
- Exploration of small molecule enzyme inhibitors
- Integration into technological platforms for medical diagnostics
