In situ destruction of halogenated Superfund contaminants with biological radical reactions

Summary

This project aims to develop novel in-situ bioremediation strategies using biological-radical systems to destroy highly halogenated Superfund contaminants like PFAS, chlorinated solvents, PCBs, and PBDEs, thereby protecting environmental health.

What they want

The project will investigate biological-radical systems for the destruction of highly halogenated compounds, including PFAS, chlorinated solvents, PCBs, and PBDEs, which are persistent environmental pollutants. Aim 1 involves using bioinformatics and molecular biology to optimize laccase systems for PFAS treatment. Aim 2 focuses on studying anaerobic radical systems like glycyl radical enzymes (GRE) and S-adenosylmethionine (SAM) for their potential in future remediation strategies. Aim 3 will integrate chemical pre-treatment with biological radical treatment and analyze microbial community dynamics. The overall goal is to develop new remediation technologies for emerging and legacy halogenated compounds in the environment.

Deliverables

Optimized laccase systems for PFAS treatment
Understanding of anaerobic radical systems (GRE, SAM) capabilities for remediation
Insights into combined chemical and biological radical treatment approaches
Data on microbial community dynamics before and after chemical treatment
New remediation approach/technologies for highly halogenated compounds

Technical requirements

Bioinformatics techniques
Molecular biology techniques
High throughput assays
Study of laccase systems
Study of glycyl radical enzymes (GRE)
Study of S-adenosylmethionine (SAM) systems
Chemical treatment methods
Microbial community dynamics analysis

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541714

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

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